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Your healthcare provider is your best source of information, especially when choosing treatment. Together, you decide what treatment may work best for you. Download these questions to help get the conversation started at your next appointment.

#1 prescribed pill
The only interferon beta that effectively treats relapsing MS in 1 shot every 2 weeks

Learn more at Plegridy.com

What is PLEGRIDY?

PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.

How do I take PLEGRIDY?Icon of an injection Every two weeks

  • PLEGRIDY is given by injection under the skin (subcutaneous injection) of your stomach (abdomen), back of upper arm, or thigh 1 time every 14 days
  • Use PLEGRIDY exactly as your healthcare provider tells you. A healthcare provider should show you how to inject your PLEGRIDY before you use it for the first time
  • When you first use PLEGRIDY, your healthcare provider may tell you to slowly increase your dose so that you can adjust to the effects of PLEGRIDY before using the full dose. You should use a PLEGRIDY starter pack to slowly adjust your dose when you begin treatment
  • Change (rotate) the site you choose with each injection to help decrease the chance that you will have an injection site reaction. Do not inject into an area of the body where the skin is irritated, reddened, bruised, infected, or scarred in any way
  • Always use a new PLEGRIDY prefilled pen or new, unopened single-use prefilled syringe for each injection

How could PLEGRIDY help me?

See how PLEGRIDY was shown in clinical studies to impact:

  • Relapses
  • Progression of physical disability
  • MRI brain lesions

Who should not use PLEGRIDY?

Do not take PLEGRIDY if you are allergic to interferon beta or peginterferon beta-1a, or any of the other ingredients in PLEGRIDY.

Find out more about PLEGRIDY >

Proven results

Learn more about how PLEGRIDY has been shown to treat relapsing forms of MS in clinical trials.

Find out how
Doctor Discussion Guide
Doctor Discussion Guide

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Understanding Important Safety Information

Before taking any treatment, it’s important to understand as much about it as possible. The Important Safety Information for a treatment describes possible side effects you may experience. It also tells you what information you need to share with your doctor before starting treatment.

On this website, the Important Safety Information appears on each specific treatment page. You'll also find the Indication, which explains the specific condition that the medication was approved to treat by the FDA.

What is PLEGRIDY?

PLEGRIDY® (peginterferon beta-1a) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.

Important Safety Information

Prescribing Information | Medication Guide

Who should not take PLEGRIDY?

  • Do not take PLEGRIDY if you are allergic to interferon beta or peginterferon beta-1a, or any of the other ingredients in PLEGRIDY.

What is the most important information I should know about PLEGRIDY?

PLEGRIDY can cause serious side effects, including:

  • Liver problems, or worsening of liver problems including liver failure and death. Symptoms may include yellowing of your skin or the white part of your eye, nausea, loss of appetite, tiredness, bleeding more easily than normal, confusion, sleepiness, dark colored urine, and pale stools. During your treatment with PLEGRIDY you will need to see your healthcare provider regularly. You will have regular blood tests to check for these possible side effects
  • Depression or suicidal thoughts. Symptoms may include new or worsening depression (feeling hopeless or bad about yourself), thoughts of hurting yourself or suicide, irritability (getting upset easily), nervousness, or new or worsening anxiety

Call your healthcare provider right away if you have any of the symptoms listed above.

Before taking PLEGRIDY, tell your healthcare provider if you:

  • Are being treated for a mental illness or had treatment in the past for any mental illness, including depression and suicidal behavior
  • Have or had liver problems, low blood cell counts, bleeding problems, heart problems, seizures (epilepsy), thyroid problems, or any kind of autoimmune disease
  • Take prescription and over-the-counter medicines, vitamins, and herbal supplements
  • Are pregnant or plan to become pregnant. It is not known if PLEGRIDY will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with PLEGRIDY
  • Are breastfeeding or plan to breastfeed. It is not known if PLEGRIDY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use PLEGRIDY

What are the possible side effects of PLEGRIDY?

PLEGRIDY may cause additional serious side effects, including:

  • Serious allergic reactions. Serious allergic reactions can happen quickly. Symptoms may include itching, swelling of the face, eyes, lips, tongue, or throat, trouble breathing, feeling faint, anxiousness, skin rash, hives, or skin bumps
  • Injection site reactions. PLEGRIDY may commonly cause redness, pain or swelling at the place where the injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected and it does not heal within a few days. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider
  • Heart problems, including congestive heart failure. While PLEGRIDY is not known to have any direct effects on the heart, some people who did not have a history of heart problems developed heart muscle problems or congestive heart failure after taking interferon beta. If you already have heart failure, PLEGRIDY may cause your heart failure to get worse. Call your healthcare provider right away if you have worsening symptoms of heart failure such as shortness of breath or swelling of your lower legs or feet while using PLEGRIDY
    • Some people using PLEGRIDY may have other heart problems, including low blood pressure, fast or abnormal heartbeat, chest pain, heart attack, or a heart muscle problem (cardiomyopathy)
  • Autoimmune diseases. Problems with easy bleeding or bruising (idiopathic thrombocytopenia), thyroid gland problems (hyperthyroidism and hypothyroidism), and autoimmune hepatitis have happened in some people who use interferon beta
  • Blood problems and changes in your blood tests. PLEGRIDY can decrease your white blood cells or platelets, which can cause an increased risk of infection, bleeding or anemia, and can cause changes in your liver function tests. Your healthcare provider should do blood tests while you use PLEGRIDY to check for side effects
  • Seizures. Some people have had seizures while taking PLEGRIDY, including people who have never had seizures before

The most common side effects of PLEGRIDY include:

  • Flu-like symptoms. Many people who take PLEGRIDY have flu-like symptoms early in the course of therapy. These symptoms are not really the flu. You cannot pass it on to anyone else. Symptoms may include: headache, muscle and joint aches, fever, chills or tiredness
    • You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers and drinking plenty of water. For many people, these symptoms lessen or go away over time

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I use PLEGRIDY?

  • See the Instructions for Use for detailed instructions to prepare for and to inject your dose of PLEGRIDY
  • Use PLEGRIDY exactly as your healthcare provider tells you. A healthcare provider should show you how to inject your PLEGRIDY before you use it for the first time
  • When you first use PLEGRIDY, your healthcare provider may tell you to slowly increase your dose so that you can adjust to the effects of PLEGRIDY before using the full dose. You should use a PLEGRIDY starter pack to slowly adjust your dose when you begin treatment
  • PLEGRIDY is given by an injection under the skin (subcutaneous injection) of your stomach, back of upper arm or thigh 1 time every 14 days
  • Change (rotate) the site you choose with each injection to help decrease the chance that you will have an injection site reaction
  • Always use a new, PLEGRIDY prefilled pen or new, unopened single-use prefilled syringe for each injection

Please see full Prescribing Information and Medication Guide.

This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is PLEGRIDY?

PLEGRIDY® (peginterferon beta-1a) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.

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